Metal-supported solid oxide fuel cell (SOFC) has a varieties of potential advantages compared to the traditional ceramic supported SOFC. However, degradation issue of metal-supported SOFC is seriously impeding its further development, in particular, the inter-diffusion and interaction of iron, chromium and nickel at substrate/anode interface is known to be a key issue responsible for cell rapid degradation. With respect to the complexity and nonlinearity of degradation mechanism, multi-scale modeling and simulation is regarded as one powerful method to gain a deep insight on degradation mechanism. In present work, multi-scale models were presented to investigate multi-scale physicochemical phenomena happening at interface of anode/substrate, with the attempt to reveal degradation mechanism. The research procedure for the above goal was addressed in detail as well.