Synthesis and Drug Release from a PH/Temperature Sensitive Bead of Poly(N-Acryloylglycinate) and Alginate

Abstract:

In this paper, a new pH/temperature sensitive beads with core-shelled structure, composed of sodium alginate and poly(N-acryloylglycinate), were prepared using as drug delivery carrier. Selecting indomethacin as a model drug, in vitro drug release behaviors were investigated at different temperatures, phosphate buffer solutions (PBS) and polymer content. At pH=2.1, the release amount of indomethacin loaded in the beads was only 2.46% while this value approached to 95.23% in pH=7.4 PBS. In addition, the release rate of indomethacin at 37°C is much higher than at 18°C.

• Periodical: Applied Mechanics and Materials (Volumes 117-119)
• Pages: 1227-1230
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.117-119.1227
• Online since: October 2011
• Authors: Kui Lin Deng, Ting Gao, Yu Bo Gou, Wei Wang, Peng Fei Zhang, Shu Liang Wang, Chun Yuan Huang, Hui Juan Shen
• Keywords: Drug Release, pH/temperature Sensitive, Poly(N-Acryloylglycinate), Sodium Alginate

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