Drug Release Behavior from a pH/Temperature Sensitive Hydrogel of Poly(N-Acryloylglycine) and Chitosan
In this study, a pH/temperature sensitive polymeric hydrogel from poly(N-acryloylglycine) and natural chitosan (PNAG-CS) was prepared via the radical polymerization. The effects of temperature and pH on the swelling behavior of PNAG-CS were systematically studied. Using caffeine as the model drug, the controlled caffeine-release from the resulting pH/temperature sensitive PNAG-CS was evaluated as functions of pH, polymer content and temperature by UV spectrophotometer.
Huixuan Zhang, Ye Han, Fuxiao Chen and Jiuba Wen
K. L. Deng et al., "Drug Release Behavior from a pH/Temperature Sensitive Hydrogel of Poly(N-Acryloylglycine) and Chitosan", Applied Mechanics and Materials, Vols. 117-119, pp. 1429-1432, 2012