Drug Release Behavior from a pH/Temperature Sensitive Hydrogel of Poly(N-Acryloylglycine) and Chitosan

Abstract:

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In this study, a pH/temperature sensitive polymeric hydrogel from poly(N-acryloylglycine) and natural chitosan (PNAG-CS) was prepared via the radical polymerization. The effects of temperature and pH on the swelling behavior of PNAG-CS were systematically studied. Using caffeine as the model drug, the controlled caffeine-release from the resulting pH/temperature sensitive PNAG-CS was evaluated as functions of pH, polymer content and temperature by UV spectrophotometer.

Info:

Periodical:

Edited by:

Huixuan Zhang, Ye Han, Fuxiao Chen and Jiuba Wen

Pages:

1429-1432

DOI:

10.4028/www.scientific.net/AMM.117-119.1429

Citation:

K. L. Deng et al., "Drug Release Behavior from a pH/Temperature Sensitive Hydrogel of Poly(N-Acryloylglycine) and Chitosan", Applied Mechanics and Materials, Vols. 117-119, pp. 1429-1432, 2012

Online since:

October 2011

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Price:

$35.00

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