Drug Release Behavior from a pH/Temperature Sensitive Hydrogel of Poly(N-Acryloylglycine) and Chitosan

Kui Lin Deng; Shu Liang Wang; Qian Li; Hong Cheng; Peng Fei Zhang; Ting Gao; Chun Yuan Huang; Chun Xiu Li

doi:10.4028/www.scientific.net/AMM.117-119.1429

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 117-119Drug Release Behavior from a pH/Temperature...

Drug Release Behavior from a pH/Temperature Sensitive Hydrogel of Poly(N-Acryloylglycine) and Chitosan

Abstract:

In this study, a pH/temperature sensitive polymeric hydrogel from poly(N-acryloylglycine) and natural chitosan (PNAG-CS) was prepared via the radical polymerization. The effects of temperature and pH on the swelling behavior of PNAG-CS were systematically studied. Using caffeine as the model drug, the controlled caffeine-release from the resulting pH/temperature sensitive PNAG-CS was evaluated as functions of pH, polymer content and temperature by UV spectrophotometer.