GT-Suite software is used to establish the simulation model of electronic fuel injection system for 16V280ZJ diesel engine. Combustion process simulation calculation is conducted to the direct injection (DI) diesel engine based on a main-post double injection scheme. Simulation parameters are modified based on the comparison with given experimental results. The calculation results effectively reflect the influence of fuel ratio and the interval angle between main and post injection over emission and fuel economy. Finally, in order to improve the engine emissions and reduce the pressure rise rate, we get the optimal injection solution for the main-post injection mode.