China’s community health services starts in 1997 and becomes the most important part of the urban health services system with the development of China’s social security system and community security. Two-way referral system in China came into being with the further development of community medical services. This paper studies the construction of two-way referral management information system based on the social security system platform using information management system and UML language based on the survey of the present implementation of two-way referral system. The two-way referral management information system includes the feasible analysis, the analysis of functional requirement, the on-stream analysis of two-way referral process, the on-stream analysis of two-way referral management information system, the design of functional configuration and functional module. The paper aims to reduce the cost of two-way referral and increase the visiting rate and medical care of community health service organization.