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Colon-Targeted Drug Delivery Microparticles Prepared Using Electrohydrodynamic Atomization

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Abstract:

Electrohydrodynamic atomization (EHDA) process was exploited to prepare drug-loaded microparticles for colon-targeted drug delivery. Field emission scanning electron microscope results showed that the particles had a size of 1.3±0.7 μm. Differential scanning calorimetry (DSC) analyses and wide-angle X-ray diffraction analyses (XRD) results similarly demonstrated that the drug DS had been totally converted into an amorphous state in the EHDA microparticles with Eudragit® L-100 as the polymer matrix. Attenuated total reflectance Fourier transform infrared analysis disclosed that the secondary interactions presented between DS and Eudragit® L100 molecules. In vitro dissolution tests verified that the microparticles had a pH-dependent and sustained drug release profile. The present study provides an easy way for developing colon-targeted drug delivery microparticles.

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Periodical:

Applied Mechanics and Materials (Volumes 130-134)

Pages:

1663-1667

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.130-134.1663

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Online since:

October 2011

Authors:

Deng Guang Yu, Xia Wang, Ping Lu, Xiao Chen, Hui Peng Zhao, Xiao Yan Li, Wei Qian, Ying Li, Yao Zu Liao

Keywords:

Colon-Targeted, Drug Delivery, Electrohydrodynamic Atomization, Microparticles, Polymer Composite

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© 2012 Trans Tech Publications Ltd. All Rights Reserved

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