Colon-Targeted Drug Delivery Microparticles Prepared Using Electrohydrodynamic Atomization

Abstract:

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Electrohydrodynamic atomization (EHDA) process was exploited to prepare drug-loaded microparticles for colon-targeted drug delivery. Field emission scanning electron microscope results showed that the particles had a size of 1.3±0.7 μm. Differential scanning calorimetry (DSC) analyses and wide-angle X-ray diffraction analyses (XRD) results similarly demonstrated that the drug DS had been totally converted into an amorphous state in the EHDA microparticles with Eudragit® L-100 as the polymer matrix. Attenuated total reflectance Fourier transform infrared analysis disclosed that the secondary interactions presented between DS and Eudragit® L100 molecules. In vitro dissolution tests verified that the microparticles had a pH-dependent and sustained drug release profile. The present study provides an easy way for developing colon-targeted drug delivery microparticles.

Info:

Periodical:

Edited by:

Han Zhao

Pages:

1663-1667

DOI:

10.4028/www.scientific.net/AMM.130-134.1663

Citation:

D. G. Yu et al., "Colon-Targeted Drug Delivery Microparticles Prepared Using Electrohydrodynamic Atomization", Applied Mechanics and Materials, Vols. 130-134, pp. 1663-1667, 2012

Online since:

October 2011

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Price:

$35.00

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