The Preparation of pH- and Thermo-Sensitive Chitosan-Based Hydrogels by Michael-Type Addition Reaction
The hydrogels based on chitosan were prepared by Michael-type addition reaction between chitosan's primary amino groups and maleimide group terminating poly (ethylene glycol) (PEG) under mild conditions. The hydrogels were characterizatied by FTIR, TG, etc. The study on the swelling behavior indicated that the hydrogels possess pH-and thermo-sensitivity. The chitosan-based hydogels crosslinked by Michael-type addition reaction have a potential application on biomaterials due to its biodegradability, biocompatibility, less toxicity and hydrophilicity.
H. L. Wei et al., "The Preparation of pH- and Thermo-Sensitive Chitosan-Based Hydrogels by Michael-Type Addition Reaction", Applied Mechanics and Materials, Vols. 130-134, pp. 2392-2395, 2012