The Preparation of pH- and Thermo-Sensitive Chitosan-Based Hydrogels by Michael-Type Addition Reaction

Hong Liang Wei; Cun Cai Ma; Hui Juan Chu; Jing Zhu

doi:10.4028/www.scientific.net/AMM.130-134.2392

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 130-134The Preparation of pH- and Thermo-Sensitive...

The Preparation of pH- and Thermo-Sensitive Chitosan-Based Hydrogels by Michael-Type Addition Reaction

Abstract:

The hydrogels based on chitosan were prepared by Michael-type addition reaction between chitosan's primary amino groups and maleimide group terminating poly (ethylene glycol) (PEG) under mild conditions. The hydrogels were characterizatied by FTIR, TG, etc. The study on the swelling behavior indicated that the hydrogels possess pH-and thermo-sensitivity. The chitosan-based hydogels crosslinked by Michael-type addition reaction have a potential application on biomaterials due to its biodegradability, biocompatibility, less toxicity and hydrophilicity.

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Periodical:

Applied Mechanics and Materials (Volumes 130-134)

Pages:

2392-2395

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.130-134.2392

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Online since:

October 2011

Authors:

Hong Liang Wei, Cun Cai Ma, Hui Juan Chu, Jing Zhu

Keywords:

Chitosan (CS), Hydrogel, Michael-Type Addition, Swelling Ratio

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