As an important part of the asphalt pavement construction, quality control is directly related to the life of road. In view of the non-uniformity issues in asphalt mixture production and construction processes, depending on the segregation standards in asphalt pavement testing, the universal volumetric chart is used to control the asphalt mixture’s volume indexes in this paper. And a PQI (pavement quality indicator) is used to make a non-destructive inspection of the pavement density. Finally, the controlling and monitoring system from asphalt mixture production to asphalt pavement construction and applying software with asphalt pavement construction quality control and quality assurance in the platform of MATLAB are developed in this paper. According to the field application, the system and software developed in this paper could be well used in the asphalt pavement construction quality control.