Algorithm Establishment with Model Experiment for Continuous-Wave Functional Near-Infrared Spectroscopy
Although functional near-infrared spectroscopy (fNIRS) has been developing as a useful tool for monitoring functional brain activity since the early 1990s, the quantification of hemoglobin concentration changes is still controversial and there are few detailed reports especially for continuous-wave (CW) instruments. By means of a two-layer model experiment mimicking hemodynamic changes in brain and mathematical analysis based on the modified Beer-Lambert law, we established an algorithm for a CW functional near-infrared spectroscopy (CW-fNIRS). The accuracy of this algorithm was validated both in comparison with direct measurements on brain tissue model and in vivo measurement upon human valsalva maneuver. This described method can also be utilized for other CW-fNIRS instruments to establish measuring algorithm.
T. Li et al., "Algorithm Establishment with Model Experiment for Continuous-Wave Functional Near-Infrared Spectroscopy", Applied Mechanics and Materials, Vols. 138-139, pp. 553-559, 2012