Every year, roughly two million patients worldwide sustain a bone grafting procedure to repair bone defects stemming from tumor, the wound, the infection, as well as other reasons [1, 2]. The bone transplantation is one of main methods to treat bone damages . The gold standard is to use autologous bone or autograft . However, both the need of the second surgery and morbidity at the extraction site [5-7] has been an incentive to search for alternative treatment. One of them is to form bone graft bone. Many materials have been widely chosen to form bone graft substitutes: metals, polymers, ceramics, dehydrate, and calcium phosphates [8-13]. Although these synthetic materials provide an immediate solution for many patients, their long-term performance is generally not satisfactory. This is often due to a mechanical property mismatch between the implant failure and tissue damage [14, 15]. The development of combined artificial bone with improved mechanical properties and enhanced biocompatibility calls for a biomimetic approach using natural bone as a guide.