Synthesis and Characterization of an Alendronate-Chitosan Conjugate

Xiao Hong Shao; Ji Qing Xu; Yan Peng Jiao; Chang Ren Zhou

doi:10.4028/www.scientific.net/AMM.140.53

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 140Synthesis and Characterization of an...

Synthesis and Characterization of an Alendronate-Chitosan Conjugate

Abstract:

The biomineral-binding alendronate-chitosan conjugate (Scheme 1) was developed as a novel drug delivery system. Alendronate was conjugated to the hydroxyl groups of chitosan, thereby maintaining the amino groups of chitosan intact. By means of FT-IR and ¹H NMR, the characterization was conducted to confirm the successful synthesis of alendronate-chitosan conjugate.

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Applied Mechanics and Materials (Volume 140)

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53-57

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https://doi.org/10.4028/www.scientific.net/AMM.140.53

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Online since:

November 2011

Authors:

Xiao Hong Shao, Ji Qing Xu, Yan Peng Jiao, Chang Ren Zhou

Keywords:

Alendronate, Chitosan (CS), Polymer-Drug Conjugates

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References

[1] F. Greco, M. J. Vicent, Combination therapy: Opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines, Adv. Drug Delivery Rev. 61 (2009) 1203-1213.

DOI: 10.1016/j.addr.2009.05.006

Google Scholar

[2] E. Siris, Alendronate in the treatment of osteoporosis: a review of the clinical trials. J Womens Health Gend Based Med, 9(2000) 599- 606.

Google Scholar

[3] P. Masarachia, M. Weinreb, R. Balena, G.A. Rodan, Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones, Bone. 19(1996) 281-290.

DOI: 10.1016/8756-3282(96)00182-2

Google Scholar

[4] H. Uludag, J. Yang, Targeting systemically administered proteins to bon by bisphosphonate conjugation. Biotechnol Prog. 18(2002) 604-611.

DOI: 10.1021/bp0200447

Google Scholar

[5] K. A. Janes, P. Calvo,M. J. Alonso, Polysaccharide colloidal particles as delivery system for macromolecules, Adv. Drug Delivery Rev. 47(2001) 83-97.

DOI: 10.1016/s0169-409x(00)00123-x

Google Scholar

[6] M. Thanou, J. C. Verhoef, H. E. Junginger, Oral drug absorption enhancement by chitosan and its derivatives, Adv. Drug Delivery Rev. 52(2001) 117.

DOI: 10.1016/s0169-409x(01)00231-9

Google Scholar

[7] G.Q. Cai, H.L. Jiang, K.H. Tu, L.Q. Wang, K.J. Zhu, A facile route for regioselective conjugation of organo-soluble polymers onto chitosan, Macromol. Biosci. 9(2009) 256-261.

DOI: 10.1002/mabi.200800153

Google Scholar

[8] R. Huang, Y. Du, J. Yang, Preparation and anticoagulant activity of carboxybutyrylated hydroxyethyl chitosan sulfates, Carbohydr. Polym. 51(2003) 431-438.

DOI: 10.1016/s0144-8617(02)00208-4

Google Scholar