Synthesis and Characterization of an Alendronate-Chitosan Conjugate
The biomineral-binding alendronate-chitosan conjugate (Scheme 1) was developed as a novel drug delivery system. Alendronate was conjugated to the hydroxyl groups of chitosan, thereby maintaining the amino groups of chitosan intact. By means of FT-IR and 1H NMR, the characterization was conducted to confirm the successful synthesis of alendronate-chitosan conjugate.
X. H. Shao et al., "Synthesis and Characterization of an Alendronate-Chitosan Conjugate", Applied Mechanics and Materials, Vol. 140, pp. 53-57, 2012