Highland Plains People AVP Gene Polymorphism and the Relationship between Hypoxic Adaptation

Wen Hua Li; Dong Ya Yuan; Min Zhang; Fang Yun Sun

doi:10.4028/www.scientific.net/AMM.140.63

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Highland Plains People AVP Gene Polymorphism and the Relationship between Hypoxic Adaptation
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Highland Plains People AVP Gene Polymorphism and the Relationship between Hypoxic Adaptation

Abstract:

Objective To investigate the plateau plains of arginine vasopressin (AVP) gene polymorphism population and hypoxic adaptation in the relationship. Methods Polymerase chain reaction and restriction fragment length polymorphism method, the indigenous Tibetan population and plains Han Chinese AVP gene polymorphism detection and analysis of genotype and allele distribution. Results Showed that 150 cases of native Tibetans in +22959 sites GG, GT, TT distribution of genotype frequencies were 46%,50.1% and 3.3%, while the plain Han people 60. %, 37.3 %and 4.7%, the difference was statistically significant (P <0.05); Tibetan plateau alleles G, T in the distribution frequency of 67.4 %and 32.6,% and 82.2% and 17.8% plains of the Han people, the difference Statistically significant (P

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Applied Mechanics and Materials (Volume 140)

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63-67

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https://doi.org/10.4028/www.scientific.net/AMM.140.63

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Online since:

November 2011

Authors:

Wen Hua Li, Dong Ya Yuan, Min Zhang, Fang Yun Sun

Keywords:

AVP Gene Polymorphism, HAN, Hypoxia, Tibetan

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References

[1] Weise A, Timmermann B, Grabherr M, et al. High-throughput sequencing of microdissected chromosomal regions[J]. Eur J Hum Genet,2010,18:457–462.

DOI: 10.1038/ejhg.2009.196

Google Scholar

[2] Tatum S.Simonson,Yingzhong Yang, Chad D. Huff, et al. Genetic Evidence for High-Altitude Adaptation in Tibet[J]. Science,2010,329:72-75.

Google Scholar

[3] Beall C M, Cavalleri G L, Deng L, et al. Natural selection on EPAS1 (HIF-alpha) associated with low hemoglobin concentration in Tibetan highlanders[J]. Proc Natl Acad Sci USA, 2010, 107: 11459–11464.

DOI: 10.1073/pnas.1002443107

Google Scholar

[4] Yi X, Liang Y, Huerta-Sanchez E, et al. Sequencing of 50 human exomes reveals adaptation to high altitude. Science,2010,329:75–78.

Google Scholar

[5] Stobdan T, Karar J, Pasha M A. High altitude adaptation: Genetic perspectives [J].High Altitude Medicine & Biology,2008, 9(2):140-147.

DOI: 10.1089/ham.2007.1076

Google Scholar

[6] Wu T Y. Tibetan - excellent one that the highland adapts to [J]. Nature,2005.(3):4

Google Scholar

[7] Li W H, Yuan D Y. Tibetan Youth and analysis for determination of plasma AVP [j], the Chinese Journal of public health, 2008，24（1）：84-85。

Google Scholar

[8] Gao Y Q. Highland military medical service［M］，Chongqing press, 2005: 35 –74。

Google Scholar

[9] Hou C R,Ma Q S. Life dwells to be living distinct heights from Tibetan plasma AVP's content research［J］. Qinghai medical college journal，2002，23（4）：1

Google Scholar