Effect of Arthrigia on Adjuvant Arthritis Rats’ IL-12

Xi Chen; Cheng Yi Zhang; Hao Gang Xue

doi:10.4028/www.scientific.net/AMM.140.43

Paper Titles

4-1BB Signal on the Function of Murine Dendritic Cells
p.24

Biocompatabiltiy of Chitosan/Poly(L-Lactic Acid) Composite Scaffolds with Three-Dimensional Honeycomb Patterned Structure
p.29

Application of Gray-Scale Texture Feature in the Diagnosis of Pulmonary Nodules
p.34

Bio-Inspired Fabrication of Polymer Composite Scaffolds with Chitosan Network inside the Pore Channels
p.38

Effect of Arthrigia on Adjuvant Arthritis Rats’ IL-12
p.43

Study on Anti-Human Herpes Virus 6 Effects of Baicalin
p.48

Synthesis and Characterization of an Alendronate-Chitosan Conjugate
p.53

Surface Modified Polylactic Acid Microspheres Reinforced Calcium Alginate Hydrogels
p.58

Highland Plains People AVP Gene Polymorphism and the Relationship between Hypoxic Adaptation
p.63

HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 140Effect of Arthrigia on Adjuvant Arthritis Rats’...

Effect of Arthrigia on Adjuvant Arthritis Rats’ IL-12

Abstract:

Rheumatoid Arthritis （RA） is a systemic chronic autoimmune disease. To study the therapeutic mechanism of effects of Skullcap Brightviolet （SB），glucosamine/chondroitin （GC），and the combination of them (named Arthrigia) on RA. With the adjuvant arthritis (AA) rat models, we observed the protective effects of oral SB, GC and Arthrigia in different concentrations on AA in rats. We further examined the immunological mechanism of the combination of them by testing the rats’ secretion of IL-12. The results showed that Arthrigia inhibited the production and secretion of IL-12 factors in some extent, and its effects are more potent the single SB or GC. The present study provides the experimental evidences for Arthrigia for its further development, clinical prevention and treatment of RA.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Applied Mechanics and Materials (Volume 140)

Pages:

43-47

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.140.43

Citation:

Cite this paper

Online since:

November 2011

Authors:

Xi Chen, Cheng Yi Zhang, Hao Gang Xue

Keywords:

Arthrigia, Glucosamine/Chondroitin (GC), IL-12, Rheumatoid Arthritis (RA), Skullcap Brightviolet (SB)

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] Dubost, Jean-Jacques. Streptococcal septic arthritis in adults. A study of 55 cases with a literature review. Joint Bone Spine Volume: 71, Issue: 4, July, 2004, pp.303-311.

DOI: 10.1016/s1297-319x(03)00122-2

Google Scholar

[2] Edwards, Jayne E.; McQuay, Henry J. Efficacy and safety of valdecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials. Pain Volume: 111, Issue: 3, October, 2004, pp.286-296.

DOI: 10.1016/j.pain.2004.07.004

Google Scholar

[3] Myers, L. K.; Tang, B.; Stuart, J. M.; Kang, A. H. The Role of IL-4 in Regulation of Murine Collagen-Induced Arthritis. Clinical Immunology Volume: 102, Issue: 2, February, 2002, pp.185-191.

DOI: 10.1006/clim.2001.5162

Google Scholar

[4] Firestein GS，Alvaro-Gracia JM，Maki R，et al. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol，2004，144（9）：3347.

DOI: 10.4049/jimmunol.144.9.3347

Google Scholar

[5] ChinJE，Lin Y. Effects of recombinant human interleukin-β on rabbit articular chondrocytes stimulation of prostanoid release and inhibition of cell growth. Arthritis and Rheum，2004，31（10）：1290.

Google Scholar

[6] Ditzel, Henrik J. The K/BxN mouse: a model of human inflammatory arthritis. Trends in Molecular Medicine. Volume: 10, Issue: 1, January, 2004, pp.40-45.

DOI: 10.1016/j.molmed.2003.11.004

Google Scholar

[7] Tada, Yoshifumi; FumitakaUshiyama, OsamuSuzuki, Noriaki et. al. Collagen-Induced Arthritis in TNF Receptor-1-Deficient Mice: TNF Receptor-2 Can Modulate Arthritis in the Absence of TNF Receptor-1. Clinical Immunology Volume: 99, Issue: 3, June, 2004, pp.325-333.

DOI: 10.1006/clim.2001.5027

Google Scholar

[8] Lu Zhizheng. Practical Chinese Medicine Rheumatology. The People's Medical Publishing House，(1996).

Google Scholar