Homogenization and Melt-Emulsification Techniques for Ibuprofen Particle Size Reduction: Effect of Tween 80 & Sonication

Abstract:

Ibuprofen suspensions were prepared by simple homogenization with melt-emulsification process. Tween 80 was used as stabilizer. The homogenized suspensions were evaluated and compared with melt emulsificated suspension. The pH value and rheology behavior were not difference. The viscosity was very low. Zeta potential was -10 to -25 mV. In this study, the suitable process to minimize particle size of ibuprofen suspension was melt emulsification follow by sonication. This process could be developed to obtain nanosuspension by adjust sonication process and improved formulation to obtain suitable nanosuspension.

• Periodical: Applied Mechanics and Materials (Volumes 229-231)
• Pages: 179-182
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.229-231.179
• Online since: November 2012
• Authors: Sarun Tuntarawongsa, Thawatchai Phaechamud
• Keywords: Homogenization, Melt-Emulsification, Particle Size, Reduction, Sonication, Tween 80

References

[1] F. Kesisoglou, S. Panmai, Y. Wu. Adv Drug Deliver Rev 59 (2007), p.631–44.

[2] P. Lakshmi, G.A. Kumar. Int J Pharm Pharm Sci 2 (2010), pp.35-40.

[3] R. Ambrus, P. Kocbek, J. Kristl, R. Sibanc, R. Rajko, P. Szabo-Revesz. Int J Pharm 381 (2009), p.153–9.

[4] P. Kocbek, S. Baumgartner, J. Kristl. Int J Pharm 312 (2006), p.179–86.

[5] J. Lee, J.Y. Choi, C.H. Park. Int J Pharm 355 (2008), p.328–36.

[6] Pavlik M. DePaul University 71 (2010), pp.1-127.