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Synthetic Glass Nanopore for Single Molecule Detection

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Abstract:

The molecular-scale pore structure, called nanopore, interacting with target molecules in its functionalized lumen, can produce characteristic changes in the pore conductance, which allows us to identify single molecules and simultaneously quantify each target species in the mixture. Nanopore sensors have been created for tremendous biomedical detections, with targets ranging from metal ions, drug compounds and cellular second messengers, to proteins and DNAs. Here we will review our recent discoveries with a lab-in-hand glass nanopore: single-molecule discrimination of chiral enantiomers with a trapped cyclodextrin, sensing of bioterrorist agent ricin and site-directed capturing a single nanoparticle.

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Mechanical and Electrical Technology IV View Preview

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Periodical:

Applied Mechanics and Materials (Volumes 229-231)

Pages:

197-200

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.229-231.197

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Cite this paper

Online since:

November 2012

Authors:

Xiu Hua Sun, Chang Lu Gao, Li Qun Gu

Keywords:

Nanopore, Single Molecule Detection, Site-Directed Capturing Nanoparticle

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© 2012 Trans Tech Publications Ltd. All Rights Reserved

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