Quantitative Structure-Activity Analyses of Nitrobenzene Toxicity to Paramecium caudatum

Jing Bo Xu; Nan Jing

doi:10.4028/www.scientific.net/AMM.295-298.113

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 295-298Quantitative Structure-Activity Analyses of...

Quantitative Structure-Activity Analyses of Nitrobenzene Toxicity to Paramecium caudatum

Abstract:

In this study IGC50 (50% inhibitory growth concentration) values of 26 nitrobenzenes were determined for population growth endpoint of Paramecium caudatum. Quantitative structure activity relationships (QSARs) were developed using log of the inverse of the IGC50 (logIGC50-1) in mole liter as the dependent variable and 6 molecular descriptors (logP, 1XⅤ, I, 1Ka, ∑σ- and ELUMO) as the independent variables. Through multiplicate regression analysis, one best QSAR equation was obtained. The equation was used to estimate IGC50 for 7 analogues.

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Applied Mechanics and Materials (Volumes 295-298)

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113-117

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https://doi.org/10.4028/www.scientific.net/AMM.295-298.113

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February 2013

Authors:

Jing Bo Xu, Nan Jing

Keywords:

Nitrobenzenes, Paramecium Caudatum, Qsars

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References

[1] T.W. Schultz, J. Seward-Nagel, K.A. Foster, V.A. Tucker: Environ. Toxicol. Vol. 19 (2004), p.1.

Google Scholar

[2] S. K. Walia, S. S. Ali and R. Brar: Pesticide Biochemistry and Physiology Vol. 73 (2002), p.131.

Google Scholar

[3] J. B. Xu, N. Jing: Journal of Hazardous Materials Vol. 203-204 (2012) , p.299.

Google Scholar

[4] T. H. Netzeva, M. Pavan, Worth A. P. Worth: QSAR Comb. Sci. Vol. 27 (2008), p.77.

DOI: 10.1002/qsar.200710099

Google Scholar

[5] P. R. Duchowicz, A. G. Mercader, F. M. Fernández: Intel. Lab. Sys. Vol. 90 (2008), p.97.

Google Scholar

[6] T. W. Schultz, T. I. Netzeva, D. W. Roberts: Chem. Res. Toxicol. Vol. 18 (2005), p.330.

Google Scholar

[7] Z. Z. Wang, Li X. D. Li: Semi-empirical molecular orbital theory and practice (Beijing Science Publishers, Beijing 1981).

Google Scholar

[8] J. W. Deneer, T. L. Sinnige, W. Seinen, J. L. M. Hermens: Aquat. Toxicol. Vol. 10 (1987b), p.115.

Google Scholar

[9] L. H. Hall, E. L. Maynard, L. B. Kier: Environ. Toxico. Chem. Vol. 8 (1989), p.783.

Google Scholar

[10] J. C. Dearden, M. T. D. Cronin, T. W. Schultz: Quant. Struct. -Act. Rela. Vol. 14 (1995), p.427.

Google Scholar