Design and Improvement on a Stress Loading Device for Ligament Tissue Engineering

Xiu De Wu; Xiong Wang

doi:10.4028/www.scientific.net/AMM.325-326.267

Paper Titles

Kinematics and Dynamics Simulation of a New Type Direct-Drive NC Turret Tool Post
p.247

Love Wave in an Isotropic Half-Space with a Graded Layer
p.252

Study on the Dynamic Behavior of the Ball Passage Vibrations Associated with a Linear Rolling Bearing
p.256

Contrasting the Parasitic Torque on a Drag-Driven VAWT through a Variable-Blade Rotor Architecture
p.260

Design and Improvement on a Stress Loading Device for Ligament Tissue Engineering
p.267

A High-Frequency High-Voltage Excitation Melting Ice Power Design
p.271

Preliminary Design and Adiabatic Analysis of a 3kW Free Piston Stirling Engine
p.277

CAD Designing for Stamped Tooth Wheels
p.283

Evaluation of CAD Model Manipulation in Desktop and Multimodal Immersive Interface
p.289

HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 325-326Design and Improvement on a Stress Loading Device...

Design and Improvement on a Stress Loading Device for Ligament Tissue Engineering

Abstract:

Strain loading control is important for addressing the complex requirements of tissue engineering in bioreactor. The stress variation laws of the engineering tissue during growth were analyzed, and the strain loading rules were determined. A new mechanical stress loading device was developed, which was able to apply complex concurrent mechanical strains to three-dimensional scaffolds independently housed in reactor chambers. The AC servo control system was used to carry out tensional and rotational displacements. Well controlled mechanical stimulations could be applied to the developing ligament tissue, through the closed-loop control system for stresses, allowed different mechanical loading patterns on the scaffolds. We analyzed the strains of scaffolds fixed in circular and planar modes. The strain, motion, and position control methods were designed. This device is suitable for the bioreactor used in ligament tissue engineering.

You might also be interested in these eBooks

Manufacturing Engineering and Process II

View Preview

Info:

Periodical:

Applied Mechanics and Materials (Volumes 325-326)

Pages:

267-270

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.325-326.267

Citation:

Cite this paper

Online since:

June 2013

Authors:

Xiu De Wu, Xiong Wang

Keywords:

Control Method, Deformation Analysis, Ligament Tissue Engineering, Multi-Dimensional Strain Loading

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] G.V. Novakovic, G.H. Altman, R. Horan, D. L. Kaplan, "Tissue engineering of ligaments," Annu. Rev. Biomed. Eng. pp.131-156, 2004.

DOI: 10.1146/annurev.bioeng.6.040803.140037

Google Scholar

[2] G.H. Altman, Helen H. Lu, R. Horan, T. Calabro, D.Ryder, D. L. Kaplan, "Advanced bioreactor with controlled application of multi-dimensional strain for tissue engineering," Transactions of the ASME,vol.124, pp.742-748, December 2002.

DOI: 10.1115/1.1519280

Google Scholar

[3] G.H. Altman, "Multi-dimensional strain bioreactor," U.S. Patent 0,219,659. (2004).

Google Scholar

[4] Cyril J.F. Kahn, Rachid Rahouadj, Xiong Wang, " A novel bioreactor for ligament tissue engineering," Bio-Medical Materials and Engineering, no.18, pp.283-287, 2008.

DOI: 10.3233/bme-2008-0538

Google Scholar

[5] Xiude Wu, Xiong Wang, "Advanced Bioreactor for Ligament Tissue Engineering," International Conference on Mechatronics and Automation, pp.1581-1586, Xi'an, China, August 2010.

Google Scholar

[6] Xiude Wu, China Patent CN201704334.(2011)

Google Scholar