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Determination of Doxorubicin Based on Luminescence Resonance Energy Transfer of NaYF4:Yb,Tm Nanoparticles
Abstract:
NaYF4:Yb,Tm nanoparticles possessing blue upconversion emission were prepared by microwave-assisted solvothermal method, and used as the donor to set up a luminescence resonance energy transfer system with doxorubicin for rapid detection of doxorubicin. There was a linear relationship of I = 4.98×102 - 9.92C (R = 0.9995) between luminescent intensity and concentration of doxorubicin in the range of 0-66.23 mmol·L-1. A detection limit of 0.69 mmol·L-1 (3s) was obtained by the LRET system with a RSD of 1.6% (60 mmol·L-1 , n=11). This approach is expected to be used for the clinical detection of doxorubicin in medicine.
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1971-1974
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July 2013
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© 2013 Trans Tech Publications Ltd. All Rights Reserved
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