The quality of hole is difficult to be guaranteed and tools wear severely in the drilling process of titanium alloy. To investigate more efficient methods to improve the quality of holes, the drilling experiments of titanium alloy Ti6Al4V were carried out under different drilling speed and different feeding speed. The drilling force was achieved through the dynamometers in the experiment. Simultaneously, a series of drilling experiment of titanium alloy was carried out with the two different shape drills and three different diameter drills. The comparison of the achieved drilling force proved that the sharpened tool is better to guarantee the quality of hole for titanium alloy Ti6Al4V.