High Performance Liquid Chromatographic Analysis of Degradation Products of Tinidazole Pills

Ting Xia; Jian Kang Wang; Tao Jiang; Jing Li

doi:10.4028/www.scientific.net/AMM.377.261

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High Performance Liquid Chromatographic Analysis of Degradation Products of Tinidazole Pills
p.261

HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 377High Performance Liquid Chromatographic Analysis...

High Performance Liquid Chromatographic Analysis of Degradation Products of Tinidazole Pills

Abstract:

To study the effect of different pH on degradation products of tinidazole pills and direct preparation of tinidazole pills, Tinidazole pills were prepared and the solution of different pH was compounded. The tinidazole content of pills and degradation products were determined by being heated at 80°C via high performance liqud chromatographic (HPLC). The number and concentration of tinidazole pills were increased with the increase of temperature and pH. Tinidazole pills in acidic conditions with the pH value within 4~5 were more stable than in neutral and alkaline conditions. It was shown that shortening the melting time and keeping pH value within 4~5 were in favor of preparation and assurance of pills quality.

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Periodical:

Applied Mechanics and Materials (Volume 377)

Pages:

261-264

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https://doi.org/10.4028/www.scientific.net/AMM.377.261

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Online since:

August 2013

Authors:

Ting Xia, Jian Kang Wang, Tao Jiang, Jing Li

Keywords:

Degradation Products, High Performance Liquid Chromatography (HPLC), pH, Tinidazole Pills

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