The Effects of Dechlorane Plus on Toxicity

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Dechlorane plus (DP) is a world-widely used flame retardant detected in the environment, biota and humans. The potential toxicity effect of DP is not well studied. In this research, mice were fed with DP-containing food. After two weeks, histopathological observation and oxidative stress was investigated in mouse liver. Our results demonstrated that over-dose DP induced inflammatory infiltration, hepatocellular swelling and oxidative stress in the mouse liver.

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4163-4166

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August 2013

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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[1] E. Hoh, L. Zhu and R.A. Hites: Dechlorane plus, a chlorinated flame retardant, in the Great Lakes, Environ Sci Technol., 40, 4, (2006), 1184-1189.

DOI: 10.1021/es051911h

Google Scholar

[2] Q. Xian, S. Siddique, T. Li, and etc: Sources and environmental behavior of dechlorane plus-a review, Environ Int., 37, 7, doi: 10. 1016/j. envint. 2011. 04. 016, (2011), 1273-1284.

DOI: 10.1016/j.envint.2011.04.016

Google Scholar

[3] OxyChem. Occidental Chemical Corporation. Dechlorane Plus Manual, downloaded from http: /www. epa. gov/HPV/pubs/summaries/dechlorp/c15635. pdf.

Google Scholar

[4] D. Crump, S. Chiu, L.T. Gauthier and etc: the effects of Dechlorane Plus on toxicity and mRNA expression in chicken embryos: a comparison of in vitro and in ovo approaches, Comp Biochem Physiol C Toxicol Pharmacol, 154, 2, doi: 10. 1016/j. cbpc. 2011. 04. 005, (2011).

DOI: 10.1016/j.cbpc.2011.04.005

Google Scholar

[5] W.J. Brock, R.E. Schroeder, C.A. McKnight and etc: Oral repeat dose and reproductive toxicity of the chlorinated flame retardant Dechlorane Plus, Int J Toxicol, 29, 6, doi: 10. 1177/1091581810384154, (2010), 582-593.

DOI: 10.1177/1091581810384154

Google Scholar

[6] Yan X., J. Zheng, K.H. Chen and etc.: Dechlorane Plus in serum from e-waste recycling workers: influence of gender and potential isomer-specific metabolism, Environ Int., 49, doi: 10. 1016/j. envint. 2012. 08. 011, (2012), 31-37.

DOI: 10.1016/j.envint.2012.08.011

Google Scholar

[7] B. Wu, S. Liu, X. Guo and etc: responses of mouse liver to dechlorane plus exposure by integrative transcriptomic and metabonomic studies, Cheng S. Environ Sci Technol, 46, 19, doi: 10. 1021/es301804t, (2012), 10758-10764.

DOI: 10.1021/es301804t

Google Scholar