Association of Polymorphism rs1333049 with Risk of Gout

Qing Yao Wang; Hui Yong Yang

doi:10.4028/www.scientific.net/AMM.380-384.4167

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 380-384Association of Polymorphism rs1333049 with Risk of...

Association of Polymorphism rs1333049 with Risk of Gout

Abstract:

Background: Several independent studies have previously demonstrated an association of some polymorphisms in 9p21 locus with coronary risk disease. So this study aimed to evalute whether the SNP rs1333049 in 9p21 locus influenced susceptibility of gout which has been described as a risk factors for coronary heart disease. Methods: One case-control study was performed consisting of 20 healthy participants and 20 patients with gout. Statistical analysis was performed by software SPSS 16.0 afer genotyping with AS-PCR method. Results: The the cases and controls were in conformity with the Hardy-Weinberg law. The genotypes and alleles in this site was no diffence between the cases and the controls. Conclusions: The number of samples is critical for statistical analysis. It is necessary to study larger samples to get small infinite errors in results.

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Periodical:

Applied Mechanics and Materials (Volumes 380-384)

Pages:

4167-4169

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.380-384.4167

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Online since:

August 2013

Authors:

Qing Yao Wang, Hui Yong Yang

Keywords:

Gout, Polymorphism, rs1333049

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