This study establishes the logistics distribution center location model under manufacturing and remanufacturing system and modifies alternative expenses and time- restricting condition s of logistics distribution center location model according to the specific feature of model under manufacturing and remanufacturing system. It’s necessary to consider all the factors during the course of establishing the logistics distribution center location model. And it is also necessary to consider effectiveness of distribution center in model and ask for the experts’ opinion and advice. A location model by combining DEA model and mixed integer programming is presented. In this model, in terms of the results of the evaluation of the efficiency of the distribution center by the DEA model, this result is regarded as a constraint of the model. Finally, An example demonstrates that the model can solve the problem of distribution centers location and provide an effective decision tool for decision-maker.