Studies on In Vitro Release Performance of Hydrophilic Drugs and Lipophilic Drugs in Amphiphilic SIS-Based Hot-Melt Pressure Sensitive Adhesives

Abstract:

In order to fabricate a kind of amphiphilic hot-melt pressure sensitive adhesives (HMPSAs) suitable for transdermal drug delivery systems (TDDS) of natural medicines, SIS-based hot-melt pressure sensitive adhesives were modified by a melt-blending method, in which a kind of hydrophilic poly (ethyl acrylate-co-methyl methacrylate-co-trimethylammonioethyl methacrylate chloride) (RLPO) and polyethylene glycol 2000 (PEG2000) were utilized. Functional RLPO and its plasticizer PEG2000 worked as a hydrophilic skeleton of amphiphilic HMPSAs. SEM and FT-IR results indicated that RLPO and SIS were partially compatible with each other through n-π complex between the n electrons of the carbonyl group of RLPO and the π electrons of the benzene rings of SIS and their compound had a good thermal stability. The phase microscope images showed that PEG could improve the compatibility between RLPO phase and SIS phase. As the ratio of SIS/RLPO/PEG equaled to 1/2/1.6, their compounds obtained bi-continuous structures. Geniposide (logP<0) and oleanic acid (logP=9.0) were chosen as representatives of hydrophilic drugs and lipophilic drugs, respectively. It was observed that both hydrophilic drugs and lipophilic drugs had a continuous release in the optimized amphiphilic HMPSAs. In addition, the release behavior of hydrophilic geniposide could be controlled by adjusting the ratio of RLPO to PEG.

• Periodical: Applied Mechanics and Materials (Volumes 395-396)
• Pages: 389-398
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.395-396.389
• Online since: September 2013
• Authors: Yong Nan Hu, Qing Wang, Yu Ming Sun, Xiao Hui Li, Xin Yi Che, Hai Hong Zhang
• Keywords: Adhesion, Drug Release, Infrared Spectra, Pressure-Sensitive, Transdermal

References

[1] X. Zhang, Y.M. Sun, Q. Wang , Z.F. Zhao , Y.N. Hu , Chinese Journal of Pharmaceuticals, 42 (2011) 37-42.

[2] D.J. Kim, H.J. Kim, G.H. Yoon, International Journal of Adhesion and Adhesives, 25(2005) 288-295.

[3] M. Sasaki, K. Fujita, M. Adachi, S. Fujii, Y. Nakamura, Y. Urahama, International Journal of Adhesion and Adhesives, 28 (2008) 372-381.

DOI: 10.1016/j.ijadhadh.2007.11.002

[4] Z.W. Yu, X.Y. Ying, W.Q. Liang, Chinese Pharmaceutical Journal, (2009) 1878-1882.

[5] M.W. Di, B. Wang, Adhesion in China, 25 (2004) 5-6.

[6] L.L. Hua, Y. Li, Q. Wang, Y.N. Hu, Z.F. Zhao, Journal of Adhesion Science and Technology, In Press (2011).

[7] P.D. Sawant, D. Luu, R. Ye, R. Buchta, 396 (2010) 45-52.

[8] Y.G. Wang, L.L. Li, H.Y. Li, Z.Y. Zhu, L. Hua, F. Lei, et al, Int J Pharmaceut, 392 (2010) 72-75.

[9] L.B. Yu, X.Q. Xie, Heilongjiang Medicine Journal, 21 (2008) 2.

[10] D.B. Kirby, J Coating Technology, 56 (1984) 93-95.

[11] N.A. Peppas, Pharm Acta Helv, 60 (1985) 110-112.

[12] P. Colombo, R. Bettini, N.A. Peppas, J Control Release, 61 (1999) 83-91.

[13] G.S. Rekhi, R.V. Nellore, A.S. Hussain, L.G. Tillman, H.J. Malinowski, L.L. Augsburger, J Control Release, 59 (1999) 327-342.

[14] P.L. Ritger, N.A. Peppas, J Control Release, 5 (1987) 23-36.

[15] P.L. Ritger, N.A. Peppas, J Control Release, 5 (1987) 37-42.

[16] E. Kang, J. Robinson, K. Park, J.X. Cheng, J Control Release, 122 (2007) 261-268.