Isocarbostyril Alkaloids and their Derivatives as Promising Antitumor Agents

Yu Bin Ji; Jia Zheng; Ning Chen; Dong Xue Song; Yan Dong; Bai Feng Wang

doi:10.4028/www.scientific.net/AMM.411-414.3150

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Isocarbostyril Alkaloids and their Derivatives as Promising Antitumor Agents
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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 411-414Isocarbostyril Alkaloids and their Derivatives as...

Isocarbostyril Alkaloids and their Derivatives as Promising Antitumor Agents

Abstract:

socarbostyril alkaloids is a kind of alkaloid does not contain basic nitrogen atoms and is represented by hydroxylated benzophenanthridone or isoquinolinone types of structure. The most widely known compounds of this group are narciclasine, lycoricidine , and pancratistatin. They have demonstrated to inhibite the proliferation of many human cancer cells, and at the same time have no affect on normal human cells under a certain dose, they have a high efficiency and low toxicity in antitumor area. Now this kind of compound has been a hot spot research to antitumor workers. The present paper reviews the origin and the antitumor function of the Isocarbostyril alkaloids.

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Periodical:

Applied Mechanics and Materials (Volumes 411-414)

Pages:

3150-3153

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.411-414.3150

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Online since:

September 2013

Authors:

Yu Bin Ji, Jia Zheng, Ning Chen, Dong Xue Song, Yan Dong, Bai Feng Wang

Keywords:

Antineoplastic, Derivatives, Isocarbostyril, Lycoricidine, Narciclasine, Pancratistatin

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