Structure-Activity Relationship of Two Typical Amaryllidaceae Isocarbostyril Alkaloids and their Derivatives

Abstract:

This paper reviews the structure-activity relationship of two typical Amaryllidaceae isocarbostyril alkaloids, narciclasine, pancratistatin and their derivatives. Varieties structures have important impacts on biological activity of Amaryllidaceae isocarbostyril alkaloids, for example, the nuclear structure of isocarbostyril, the stereochemistry of the B/C ring junction, the C7-hydroxy of ring A, hydroxies of ring C and so on. This study is conducive to find other active groups, conduct structural modifications and provide the rational basis for designing drugs molecular.

• Periodical: Applied Mechanics and Materials (Volumes 411-414)
• Pages: 3158-3161
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.411-414.3158
• Online since: September 2013
• Authors: Yu Bin Ji, Yan Dong, Ning Chen, Dong Xue Song, Jia Zheng
• Keywords: Amaryllidaceae, Isocarbostyril Alkaloids, Structure-Activity Relationship

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