The Noise Analysis of Fluid Systemsin Solid-State Nanopore Sensors

Song Ying; Lei Wang; Wen Yuan Zhao

doi:10.4028/www.scientific.net/AMM.419.517

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 419The Noise Analysis of Fluid Systemsin Solid-State...

The Noise Analysis of Fluid Systemsin Solid-State Nanopore Sensors

Abstract:

The solid-state nanopore sensor offers a versatile platform for the rapid, label-free electrical detection and analysis of single molecules, especially on DNA sequencing. However, the overall signal-to-noise ratio (SNA) is a major challenge in sequencing applications. In our work, two different fluid systems made by metal and plexiglass have been designed to improve the signal to noise ratio of the solid-state nanopore sensor. From the measurements on the noise power spectra with a variety of conditions, it is found that plexiglass fluid system coupled with shielding box produces a good quality of electric signals on nanopore sensors.

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Periodical:

Applied Mechanics and Materials (Volume 419)

Pages:

517-520

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.419.517

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Online since:

October 2013

Authors:

Song Ying, Lei Wang, Wen Yuan Zhao

Keywords:

Fluid, Noise Analysis, Solid-State Nanopore

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