A Regulatory Network of G2/M Phase Transition for DNA Damage

Abstract:

A regulatory network of G2/M phase transition influenced by different intensities of DNA damage is modeled. It contains the sub-modules of P53-Mdm2 feedback loop and G2/M phase transition process. To investigate the robustness of the regulatory network, a sensitivity analysis of kinetic parameters in the proposed mathematical model is implemented to select the most significant kinetic parameters, which are relevant to key proteins involved in G2/M phase transition. Subsequently, the statistical hypothesis testing is employed to evaluate the influence of perturbations on the G2/M regulatory network. The results indicate that G2/M regulatory network is robust to DNA damage signal when perturbations are very small that is consistent with the experimental observations.

• Periodical: Applied Mechanics and Materials (Volumes 444-445)
• Pages: 1182-1186
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.444-445.1182
• Online since: October 2013
• Authors: L.W. Zhang, K.M. Liew
• Keywords: DNA Damage, G2/M Regulatory Network, Modeling

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