Glycophorin a Expression in HEL-92 Cells Treated with Silica Gel Particles

Nien Tzu Keng; Chang Shu Tsai; Ya Yun Chen; Sheng Yu Kao; Wei Chung Liu

doi:10.4028/www.scientific.net/AMM.459.130

Paper Titles

Solid Oxide Electrolysis Cell Systems — Variant Analysis of the Structures and Parameters
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An Automatical Matching Method Applied in Kinematics Measurement for the Flapping Rotary Wing
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Fault Diagnosis of VCM Type AF Actuator Module for Phone Camera by Vibration Analysis
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Glycophorin a Expression in HEL-92 Cells Treated with Silica Gel Particles
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Detection for Rail Route State Deformation Based on Trap-Down Inertial Technology
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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 459Glycophorin a Expression in HEL-92 Cells Treated...

Glycophorin a Expression in HEL-92 Cells Treated with Silica Gel Particles

Abstract:

In recent years, silica-gel-containing materials have formed components of biomaterials that can contact stem cells. However, the effects of silica gel particles on erythrogenesis have not been well-established. In this study, we evaluated the erythrogenic effects of silica gel particles on bone marrow cells and stromal cells pretreated with N-acetyl-L-cysteine (NAC) for 1 h prior to exposure to the silica gel particles. Our results showed that the numbers of erythrocytes in the bone marrow cells increased considerably following treatment with the silica gel particles. In addition, the expression of glycophorin A, an erythroid marker, was upregulated in the HEL-92 cells compared with the control cells. However, NAC pretreatment inhibited erythrogenic effects. Our study results suggest that silica gel particles might stimulate the differentiation of bone marrow cells to erythrocytes by increasing the generation of reactive oxygen species.

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Applied Mechanics and Mechanical Engineering IV

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Applied Mechanics and Materials (Volume 459)

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130-135

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https://doi.org/10.4028/www.scientific.net/AMM.459.130

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Online since:

October 2013

Authors:

Nien Tzu Keng, Chang Shu Tsai, Ya Yun Chen, Sheng Yu Kao, Wei Chung Liu*

Keywords:

Erythrogenesis, Glycophorin A, Silica Gel Particle

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