Frequency Analysis of Bioimpedance Variations in Human Bladder during Changes of Urine Volume's States

Abstract:

To verify the hypothesis that the variations of bioimpedance can reflect the status of bladder volume during natural bladder filling. We chose 10 healthy, male volunteers by recording different bladder filling stages using bioimpedance and ECG measurement. The signal measurement acquisition device was design by Sun Yat-sen University. Bioimpedance measurement was employed four silver-silver chloride compound electrodes, two of which are stimulating electrodes, and the others are measuring electrodes. Each electrode is attached to the lower abdomen, the mapping position of urinary bladder. Using Fourier analysis, the bioimpedance signals in different stages were analyzed. During natural bladder filling, subjects were asked to report real sensations. Sensations intensity increased with urine volume increase. Bioimpence power spectrum density (PSD) was related with sensation intensity. During natural bladder filling, PSD revealed two parameters with 0.04-0.15 Hz (low frequency, LF), and 0.15-0.4 Hz (high frequency, HF), which were observed under different bladder sensations. In natural bladder filling, the HF spectrum power is increased, in parallel with an inconspicuous change in LF spectrum. With the ECG signal analysis, the reaults revealed spectrum powers were explained by the autonomic nervous regulation. The novel method can assess the states of bladder volume during natural bladder filling.

• Periodical: Applied Mechanics and Materials (Volumes 475-476)
• Pages: 177-183
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.475-476.177
• Online since: December 2013
• Authors: Qian Wang, Guang Min Zhou, Guan Zheng Liu*
• Keywords: Bioimpedance, Bladder Volume, Frequency, Natural Filling, Spectrum Power

References

[1] Kim C T, Linsenmeyer T A, Kim H. Bladder volume measurement with electrical impedance analysis in spinal cord-injured patients1. American Journal of Physical Medicine & Rehabilitation, 1998, 77(6): 498-502.

DOI: 10.1097/00002060-199811000-00009

[2] Abbey J C, Close L. Electrical impedance measurement of urinary bladder fullness. The Journal of Microwave Power, 1983, 18(3): 305–309.

DOI: 10.1080/16070658.1983.11689335

[3] Kodama H, Hieda I, Kuchinomachi Y. Non-invasive ultrasonic urination sensor for ambulatory patient support. Methods of Information in Medicine, 1994, 33(1): 97-100.

DOI: 10.1055/s-0038-1634979

[4] Athwal B S, Berkley K J, Hussain I. Brain responses to changes in bladder volume and urge to void in healthy men. Brain. 2001, 124(2): 369-377.

DOI: 10.1093/brain/124.2.369

[5] Mudraya I S, Revenku S V, Nesterov A V. Bioimpedance harmonic analysis as a tool to simultaneously assess circulation and nervous control. Physiological Measurement, 2011, 32(7): 959-976.

DOI: 10.1088/0967-3334/32/7/s17

[6] Waltz F, Frederick M. Bladder volume sensing by resistance measurement. Ieee Transactions on Biomedical Engineering, 1971, 18(1): 42-46.

[7] Wachter S G, Heeringa R, Koeveringe G A. On the nature of bladder sensation: the concept of sensory modulation. Neurourology and urodynamics. 2011, 30(7): 1220-1226.

DOI: 10.1002/nau.21038

[8] Drinkhill M J, Mary D A S A G, Ramadan M R M. The effect of distension of the urinaru bladder on activity in efferent renal fibres in anaesthetized dogs. Journal of Physiology, 1989, 409(2): 357-369.

DOI: 10.1113/jphysiol.1989.sp017502

[9] Lynne C W. Organization of sympathetic responses to distension of urinary bladder. Regulatory, Integrative and Comparative Physiology, 1985, 248(2): 236-240.

DOI: 10.1152/ajpregu.1985.248.2.r236

[10] Bertil F M, Gert Holstege. The central nervous system control of micturition in cats and humans. Behavioural Brain Research, 1998, 92(2): 119-125.

DOI: 10.1016/s0166-4328(97)00184-8

[11] Derek Griffiths. Imaging bladder sensations. Neurourology and Urodynamics, 2007, 26(2): 899-903.

DOI: 10.1002/nau.20488

[12] Heeringa R, Koeveringe G A, Kerrebroech P E V. Degree of urge, perception of bladder fullness and bladder volume: how are they related? The Journal of Urology, 2011, 186(4): 1352-1357.

DOI: 10.1016/j.juro.2011.05.050

[13] Heeringa R, Koeveringe, GA, Kerrebroeck P.E.V. Forced diuresis as a tool for the non-invasive evaluation of bladder sensation. Neurourology and Urodynamics, 2010, 29: 909.

[14] Gill B C, Fletter P C, Zaszczurynski P J. Feasibility of fluid volume conductance to assess bladder volume. Neurourology and Urodynamics, 2008, 27(6): 525-531.

DOI: 10.1002/nau.20551

[15] Liao W C, Jaw F S. A noninvasive evaluation of autonomic nervous system dysfunction in women with an overactive bladder. International Journal of Gynecology and Obstetrics, 2010, 110(1): 12-17.

DOI: 10.1016/j.ijgo.2010.03.007

[16] Ness T J, Richter H, Varner R. A psychophysical study of discomfort produced by repeated filling of the urinary bladder. Pain, 1998, 76(1-2): 61-69.

DOI: 10.1016/s0304-3959(98)00023-2

[17] Wachter S D, Wyndaele J J. Frequency volume charts: a tool to evaluate bladder sensation. Neurourology and Urodynamics, 2003, 22(7): 638-642.

DOI: 10.1002/nau.10160

[18] Boyle J, Bidargaddi N, Sarela A. Automatic detection of respiration rate from ambulatory single-lead ECG. Ieee Transaction Information Technology Biomedicine, 2009, 13(6): 890–896.

DOI: 10.1109/titb.2009.2031239

[19] Bristow S E, Neal D E. Ambulatory urodynamics. British Journal of Urology, 1996, 77(3): 272-274.

[20] Willemsen G H, De J, Klaver C H. Ambulatory monitoring of the impedance cardiogram. Psychophysiology, 1996, 33(2): 184-193.

DOI: 10.1111/j.1469-8986.1996.tb02122.x

[21] Griffiths C J, Assi M S, Styles R A. Urological neurology and urodynamics. The Journal of Urology, 1989, 142(1): 780-784.

[22] Kechtkar A, Mesbahi A, Mehnati P. The effect of bladder volume changes on the measured electrical impedance of the urothelium. International Journal of Biomedical Engineering and Technology, 2008, 1(3): 287-292.

DOI: 10.1504/ijbet.2008.016962

[23] Robertson A S, Griffiths C J, Ramsden P D. Bladder function in healthy volunteers: ambulatory monitoring and conventional urodynamic studies. British Journal of Urology, 1994, 73(3): 242-249.

DOI: 10.1111/j.1464-410x.1994.tb07512.x

[24] Provost B, Sawan M. Proposed new bladder volume monitoring device based on impedance measurement. Journal of Medical and Biological Engineering, 1997, 35(6): 691–694.

DOI: 10.1007/bf02510979