Building on three theoretical paradigms (student model, ICAI model, and multi-dimension education immune agent), some intelligent techniques are proposed and designed to teach Fuzzy Mathematics and Science of Artificial Immune System in a web-based way. The goal of the teaching methodology is a new learning, which is interactive, sharing, open, cooperative, and autonomous. The great difference between traditional approaches for teaching such knowledge and the new approach in this paper is the centre of teaching. The traditional teaching is centered with teachers but the new teaching is centered with students. The teaching system for Fuzzy Mathematics and Science of Artificial Immune System is a virtual classroom based on the web, and the two courses are designed as web-based courses. Moreover, for Science of Artificial Immune System, the web-based course system is a typical artificial immune system in fact, and students can learn more real knowledge from the web-based course immune system.