A Mathematical Framework for Cellular Repair Mechanisms under Genomic Stress Based on Kinetic Theory Approach

Abstract:

Generally, a cell can trigger its self-defense mechanism in response to genomic stress under acute perturbations from outer environment. To investigate the dynamic kinetics of cellular repair mechanisms in fighting against genomic stress, a mathematical model of representing and analyzing DNA damage generation and repair process is proposed under acute Ion Radiation (IR) by using the Kinetic Theory of Active Particles (KTAP). In this paper, we focus on describing a mathematical framework of Cellular Repair System (CRS). We also present the dynamic processes of Double Strand Breaks (DSBs) and Repair Protein (RP) generating, DSB-protein complexes (DSBCs) synthesizing, and toxins accumulating under continuous radiation time.

• Periodical: Applied Mechanics and Materials (Volumes 52-54)
• Pages: 7-12
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.52-54.7
• Online since: March 2011
• Authors: Jin Peng Qi, Ying Zhu, Yong Sheng Ding
• Keywords: Cellular Repair, DNA Damage, IR, KTAP, Modeling

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