Degradable Scaffold Microstructure of Artificial Bioactive Bone Fabricated by 3D Braiding Method

Abstract:

A novel fabrication of degradable scaffold is presented by using several biomaterials and growth factor (GF). Chitosan fibers can be braided into the internal fiber microstructure of the scaffold by a three-dimensional braiding (3DB) method, and rapid prototype & rapid tools techniques can be used to rapidly fabricate the outer shape mold of the scaffold. The scaffolds with 3D fiber architecture had obviously accelerated bone regeneration in comparison with the control. In detail, the materials biodegraded inside and outside and the bone ingrowth first occurred along the chitosan fibers in the scaffold. In summary, the method in this paper not only can be easily shaped but also cannot change the bio-properties of materials and GF since it does not need high temperature sintering and not produce heat, so the actions of the several biomaterials for bone regeneration interacted simultaneously through the interconnectivity macrochannels in the in-vivo scaffolds, which left by the biodegradation of the internal fiber.

• Periodical: Applied Mechanics and Materials (Volume 610)
• Pages: 980-983
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.610.980
• Online since: August 2014
• Authors: Jie Liu*
• Keywords: Artificial Bone, Bionic Microstructure, Rapid Prototyping, Scaffold Microstructure, Three-Dimensional Braiding

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