The Application of External Drainage from Intestinal Cavity in the Surgical Treatment for Neonates with Necrotizing Enterocolitis

Abstract:

Object:To explore the feasibility and effects of external drainage from intestinal cavity in the surgical treatment for the neonates with necrotizing enterocolitis. Methods: A retrospective analysis was conduct on 22 cases of newborns with extensive and multiple intestinal necrosis found intraoperatively, all of which could not accept first-stage resected, treated by traditional operation or by external drainage from intestinal cavity between January, 2008 to January 2013. Duration of operation, amount of bleeding, and the survival rate after operation were compared between the two groups, which were divided by surgical methods. Results: No significant difference was observed in age, amount of bleeding and body weight (P>0.05) between the two groups. However, duration of operation and the survival rate after operation were significantly shorter in the patients by external drainage from intestinal cavity than the patients by traditional operation (P<0.05). Conclusion: To compare traditional operation or external drainage from intestinal cavity of necrotizing enterocolitis in neonates, a retrospective analysis conducted by us showed the feasibility and effects of external drainage from intestinal cavity of necrotizing enterocolitis in neonates, and a significant advantage in duration of operation and the survival rate after operation.

• Periodical: Applied Mechanics and Materials (Volume 618)
• Pages: 388-391
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.618.388
• Online since: August 2014
• Authors: Ji Xue Zhao, Chuan Zhang, Chun Yu Dong, Xue Song Zhao, Xin Fu*
• Keywords: External Drainage, Necrotizing Enterocolitis, Neonates

References

[1] Yi Jiang. The progression of diagnosis and treatment for necrotizing enterocolitis in neonates[J]. China Journal of Neonates, 2006, 21(2): 122-124.

[2] Thompson AM, Bizzarro MJ. Necrotizing enterocolitis in new borns: Pathogenesis, prevention and management[J]. Drugs, 2008, 68(9): 1227-1238.

DOI: 10.2165/00003495-200868090-00004

[3] Hongri Zha, Binghong Zhang, Lei Shi. Influence of intestinal trefoil factor on Interleukin -1 in rats with colonitis [J]. Journal of Applied Clinical Pediatrics, 2009, 24(7): 513-514.

[4] Qinmiao Lin, Yongbiao Wang, ZR Li. Surgical treatment on necrotizing enterocolitis in newborns [J]. Journal of Applied Clinical Pediatrics. 2010, 6（11）814-816.

[5] HY Wu, Y Yang. A analysis on risk factors in necrotizing enterocolitis in newborns. Chinese And Foreign Medical Research. 2013, 11(32): 38-39.

[6] Neu J. Necrotizing enterocolitis: the search for a unifying pathogenic theory leading to prevention. Pediatr Clin North Am 1996; 43: 409.

[7] Tepas JJ 3rd, Sharma R, Leaphart CL, et al. Timing of surgical intervention in necrotizing enterocolitis can be determined by trajectory of metabolic derangement. J Pediatr Surg 2010; 45: 310.

DOI: 10.1016/j.jpedsurg.2009.10.069

[8] Moss RL, Dimmitt RA, Barnhart DC, et al. Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation. N Engl J Med 2006; 354: 2225.

DOI: 10.1056/nejmx060049

[9] Rees CM, Eaton S, Kiely EM, et al. Peritoneal drainage or laparotomy for neonatal bowel perforation? A randomized controlled trial. Ann Surg 2008; 248: 44.

DOI: 10.1097/sla.0b013e318176bf81

[10] Rees CM, Eaton S, Khoo AK, et al. Peritoneal drainage does not stabilize extremely low birth weight infants with perforated bowel: data from the NET Trial. J Pediatr Surg 2010; 45: 324.

DOI: 10.1016/j.jpedsurg.2009.10.066