This paper models the auto wheel by UG, and made analysis through ANSYS Workbench software. The result of finite element analysis shows that the maximum stress is much less than the allowable stress of aluminum alloy wheels. So auto wheels can be optimized further. Then structural optimization is made to minimize the weight of the wheel. The static analysis and fatigue analysis to the optimized wheel is made then. The results of equivalent stress, equivalent elastic strain and total deformation are similar with the results that before optimize, but its weight is decreased. It gains the goal of lighting weight, decreasing fuel consumption and reducing pollution.