The Preparation and In Vitro Release Study of the Novel Changchun Amine Sustained-Release Capsules

Abstract:

Objective: to prepare sustained-release capsules, changchun amine build release degree determination method, study its drug release characteristics and compared with the reference preparation. Methods: using ordinary dissolution apparatus and fiber stripping analyzer to determine the in vitro release of sustained-release capsules. The content determination method, drug to pH 1.5 sodium chloride for the release of the medium of hydrochloric acid solution, using ultraviolet spectrophotometry to release a quantity, at the same time by optical real-time test evaluation of homemade consistency and reference formulation of drug release. Results: the analysis method can be effectively used to build the release of sustained-release capsules to measure, two kinds of similarity factor is more than 50, drug release characteristics match each batch sample, quality and stability. Conclusion: the self-made samples and reference preparation have similar in vitro release characteristics of homemade capsule good slow release effect, drug release and stability.

• Periodical: Applied Mechanics and Materials (Volumes 651-653)
• Pages: 313-316
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.651-653.313
• Online since: September 2014
• Authors: Ping Liu*, Jin Liang Zhang
• Keywords: Changchun Amine, Optical Fiber Drug Dissolution Real-Time Meter, Release Degree, Similarity Factor, Slow-Release Characteristics

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