Modeling and Simulation Keloid Scar Formation from Biphasic Contact Blunt-Prosthesis

Abstract:

The definition of the "prosthetic man" system represents the recording, gathering data, identifying problems, formulating hypotheses and decision making for therapeutic interventions processes. The analyzing of this problem has led to the need to study in detail the changes that occur at the interface of the blunt-liner-socket. The mathematic methods of the kinetic theory can be used to develop models described by equations which characterizes the behavior of the particle group based on a description of the microscopically interactions. Interactions that are taken into account are as: conservative interactions that alter the microscopic activity; Proliferation or destruction interactions, the birth or death of a particle; stochastic interactions that modify speed according to a speed leap process. The causes of release and key changes responsible for the formation of a keloid scar remain elusive and there is no satisfactory treatment for this disorder. A current approach in tissue engineering is to use a three-dimensional precursor similar to a tissue of cells called matrix (scaffold) for growth (cell density localized spatially and temporally). We thus propose a mathematical model and its numerical implementation in Matlab, using finite differences, to describe the development and distribution of cells in such arrays. In addition, we propose an algorithm to optimize the model parameters in order to minimize the error occurred between the experimental data and the numerical generated data.

• Periodical: Applied Mechanics and Materials (Volume 658)
• Pages: 489-494
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.658.489
• Online since: October 2014
• Authors: Marius Turnea*, Mariana Rotariu, Dragos Arotaritei, Mihai Ilea
• Keywords: Blunt, Keloid Scar, Mathematical Modeling, Numerical Simulation, Prosthesis

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