Based on the establishment of a two-dimensional model, a numerical simulation was conducted in this paper to study the flow boiling and heat transfer characteristics of ethanol in a corrugated mini-channel. User defined functions were employed to describe the key processes of heat and mass exchange at the phase interface. Bubble growth profile was monitored over time and its influence on system pressure drop and heat transfer coefficient was also analyzed. The simulation result shows that the nucleation sites tend to distribute near the internal peaks of the heating wall due to the enhanced local turbulence. The system pressure drop increases over the heating time and fluctuates within a certain range. The heat transfer coefficient decreases with increasing quality, and this trend is consistent with the result of similar experimental studies.