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Found Robust Calibration Model in Fermentation Process by Combining Different Sample Sets
Abstract:
Robust calibration model is the key factor for spectroscopic measurement. The commonly used way is build calibration model by crude samples collected from process. There are two deficiencies in fermentation processes in that: matrix effects variation always existed for different batch of fermentation and, chance correlation is sure existed which spoil robust of calibration model. In the research being presented, method of overcoming the weakness is examined. By combing the standard analyte and fermentation broth and spiking solvend, the calibration model can correlate specific spectral features only with the measured analyte concentrations so have good robustness.
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372-375
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Online since:
October 2014
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© 2014 Trans Tech Publications Ltd. All Rights Reserved
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