Synthesis of a Cholesterylated Compound Containing Carboxyl Functional with PEG2000 Chain for Hepatic Targeting Liposome Ligand

Xiao Chun Wu; Li Hai; Yong Wu

doi:10.4028/www.scientific.net/AMM.668-669.79

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 668-669Synthesis of a Cholesterylated Compound Containing...

Synthesis of a Cholesterylated Compound Containing Carboxyl Functional with PEG2000 Chain for Hepatic Targeting Liposome Ligand

Abstract:

A carboxyl functional cholesterylated compound for hepatic targeting liposome ligand T₁ was synthesized. Cholesterol as starting material, after esterification with p-toluenesulfonyl chloride to get cholesterol tosylate M₄, then etherification with tetraethylene glycol to get hydroxyl functional M₃, M₃ react react with methanesulfonyl chloride to get M_2,M₂was elongated by reaction with PEG2000 to get M₁ and M₁ react with succine anhydride get T₁_. The target compounds afford cholesterylated hepatic targeting liposome ligands.

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Periodical:

Applied Mechanics and Materials (Volumes 668-669)

Pages:

79-82

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.668-669.79

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Online since:

October 2014

Authors:

Xiao Chun Wu*, Li Hai, Yong Wu

Keywords:

Carboxyl Functional Group, Cholesterylated Compounds, Hepatic Targeting, Synthesis

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