Effects of Smoking on Serum SOD and GSH-PX Activities and MDA Contents in Rats with Gastric Ulcer

Abstract:

In this study, SD rats were used to establish an acetic acid-induced rat gastric ulcer model, and SOD and GSH-PX activities and MDA contents in rats with the gastric ulcer induced by acetic acid were measured. The results showed that smoking could delay the healing of gastric ulcer induced by acetic acid and aggravate the ulceration; compared with those in the model group, serum SOD, GSH-PX activities were significantly reduced, and MDA levels were significantly elevated, in rats with the gastric ulcer induced by acetic acid, suggesting that smoking may reduce the body's antioxidant capacity. The results indicate that smoking may induce or aggravate gastric ulcer by reducing the activity of serum SOD and GSH-PX, and elevating the content of serum MDA in rats with acetic acid-induced gastric ulcer, to affect the metabolism of oxygen free radicals to cause the oxidative damage.

• Periodical: Applied Mechanics and Materials (Volumes 675-677)
• Pages: 126-129
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.675-677.126
• Online since: October 2014
• Authors: Shu Jing, Wei Hai Jiang, Wei Sun*
• Keywords: GSH-PX, MDA, Smoking, SOD, Ulcer

References

[1] T.C. Huang, C.L. Lee. Diagnosis, Treatment, and Outcome in Patients with Bleeding Peptic Ulcers and Helicobacter pylori Infections. Biomed Res Int. 6 (2014)108-115.

DOI: 10.1155/2014/658108

[2] Z. Keshavarzi, T.M. Rezapour, M. Vatanchian, M. Zare Hesari, H. Nabizade Haghighi, M. Izanlu, M. Sabaghian, K. Shahveisi. The effects of aqueous extract of Aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid- induced gastric ulcer in male rats. Avicenna J Phytomed. 4(2014).

DOI: 10.29252/jnkums.6.2.347

[3] V.A. Koval'ova, A. Shevchenko, L.I. Ostapchenko. Effects of natural antioxidants on the content of lipids, proteins and carbohydrates in rat's gastric mucosal cells under experimental ulceration. Fiziol Zh. 60(2014) 70-74.

DOI: 10.15407/fz60.02.070

[4] S.S. Al-Rejaie, H.M. Abuohashish, M.M. Al-Enazi, A.H. Al-Assaf, M.Y. Parmar, M.M. Ahmed. Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats. World J Gastroenterol.  19(2013)5633-5644.

DOI: 10.3748/wjg.v19.i34.5633

[5] Al Batran R1, Al-Bayaty F, Jamil Al-Obaidi MM, Abdualkader AM, Hadi HA, Ali HM, Abdulla MA. In vivo antioxidant and antiulcer activity of Parkia speciosa ethanolic leaf extract against ethanol-induced gastriculcer in rats. PLoS One.  28 (2013).

DOI: 10.1371/journal.pone.0064751