Fabrication of Poly Caprolactone (PCL) Based Microspheres for Drug Delivery and Tissue Engineering Application

Goon Chia Nyoke; Naznin Sultana

doi:10.4028/www.scientific.net/AMM.695.191

Paper Titles

Hydroxyl Terminated Natural Rubber (HTNR) as a Binder in Solid Rocket Propellant
p.174

Investigations on Composite Flexural Behaviour with Inclusion of CNT Enhanced Silica Aerogel in Epoxy Nanocomposites
p.179

Synthesis and Application of Carbon Cryogel Beads Using Coconut Husk for Dye Removal
p.183

Effects of the Processing Methods on the Gas Permeability of PLA/Sepiolite Thin Films: Solution Casting versus Thermo Compression
p.187

Fabrication of Poly Caprolactone (PCL) Based Microspheres for Drug Delivery and Tissue Engineering Application
p.191

Fabrication and Characterization of PCL/GE-Based Electrospun Nanofibers for Tissue Engineering and Drug Delivery Application
p.195

Fabrication of BSA Loaded Poly(Caprolactone) (PCL) Microsphere Incorporated Chitosan Scaffolds for Tissues Engineering Application
p.199

Polycaprolactone(PCL)/Chitosan(Cs)-Based Scaffold by Freeze Drying Technique for Tissue Engineering and Drug Delivery Application
p.203

Synthesis of Nano-Polyaniline Using Different Ultrasonic Wave
p.207

HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 695Fabrication of Poly Caprolactone (PCL) Based...

Fabrication of Poly Caprolactone (PCL) Based Microspheres for Drug Delivery and Tissue Engineering Application

Abstract:

This paper reports the fabrication of poly (caprolactone) (PCL) based biodegradable microspheres using freeze-drying technique for drug delivery and tissue engineering application. Microspheres play an important role in tissue engineering and drug delivery applications. The properties can determine the success or failure of the development of the materials. Biodegradable and biocompatible synthetic polymer, PCL was used to fabricate biodegradable microspheres in this study. Through a double emulsion and freeze-drying technique, the microspheres were produced. Different concentrations of polymers were used to fabricate the microspheres. The microspheres were characterized using different techniques.

You might also be interested in these eBooks

Advanced Research in Materials and Engineering Applications

View Preview

Info:

Periodical:

Applied Mechanics and Materials (Volume 695)

Pages:

191-194

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.695.191

Citation:

Cite this paper

Online since:

November 2014

Authors:

Goon Chia Nyoke, Naznin Sultana*

Keywords:

Microspheres, Poly (Caprolactone) (PCL), Polyvinyl Alcohol (PVA), Scanning Electron Microscopy (SEM), Tissue Engineering

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] D.H. Kempen, L. Lu, X Zu, W.J. Dhert, B.L. Currier and M.J. Yaszemski: Controlled drug release from a novel injectable biodegradable microsphere/scaffold composite based on poly(propylene fumarate. J. Biomed. Mater. Res. A Vol. 7 (2006).

DOI: 10.1002/jbm.a.30336

Google Scholar

[2] A.J. DeFail, C. R Chu, N. Izzo and K.G. Marra: Controlled release of bioactive TGF-beta 1 from microspheres embedded within biodegradable hydrogels. Biomat. Vol. 27 (2006), pp.1579-1585.

DOI: 10.1016/j.biomaterials.2005.08.013

Google Scholar

[3] B.S. Zolnik, P.E. Leary and D.J. Burgess: Elevated temperature accelerated release testing of PLGA microspheres. J. Cont. Release Vol. 112 (2006), pp.293-300.

DOI: 10.1016/j.jconrel.2006.02.015

Google Scholar

[4] W.L. Suchane, P. Shuk, K. Byrappa, R.E. Riman, K.S. TenHuisen and V.F. Janas: Mechanochemical-hydrothermal synthesis of carbonated apatite powders at room temperature. Biomat. Vol. 23 (2002) pp.699-710.

DOI: 10.1016/s0142-9612(01)00158-2

Google Scholar

[5] M. Labet and W. Thielemans: Synthesis of polycaprolactone: a review. Chem. Soc. Rev. Vol. 38 (2009), pp.3484-3504.

DOI: 10.1039/b820162p

Google Scholar

[6] T. Kean, S. Roth and M. Thanou: Trimethylated chitosans as non-viral gene delivery vectors: cytotoxiticy and transfection efficiency. J. Cont. Release Vol. 103 (2005), pp.643-653.

DOI: 10.1016/j.jconrel.2005.01.001

Google Scholar

[7] N. Bhattarai, Z. Li, J. Gunn, M. Leung, A. Cooper, D. Edmondson, O. Veiseh, M. -H. Chen, Y. Zhang, R.G. Ellenbogen and M. Zhang: Natural-synthetic polyblend nanofibers for biomedical applications. J. Adv. Mat. Vol. 21 (2009), pp.2792-2797.

DOI: 10.1002/adma.200802513

Google Scholar

[8] X. Yang, X. Chen and H. Wang: Acceleration of osteogenic differentiation of preosteoblastic cells by chitosan containing nanofibrous scaffolds. J. Biomacromolecules Vol. 8 (2007), pp.807-816.

DOI: 10.1021/bm900623j

Google Scholar

[9] F. Roozbahani, N. Sultana, A. F. Ismail, and Hamed Nouparvar, Effects of Chitosan Alkali Pretreatment on the Preparation of Electrospun PCL/Chitosan Blend Nanofibrous Scaffolds for Tissue Engineering Application, Journal of Nanomaterials. 2013(2013).

DOI: 10.1155/2013/641502

Google Scholar

[10] A.K. Moghe, R. Hufenus, S.M. Hudson and B.S. Gupta: Effect of the addition of a fugitive salt on of polymer. Polymer Vol. 50 (2009), pp.3311-3318.

DOI: 10.1016/j.polymer.2009.04.063

Google Scholar

[11] N. Sultana and T. H. Khan: Water Absorption and Diffusion Characteristics of Nanohydroxyapatite (nHA) and Poly(hydroxybutyrate-co-hydroxyvalerate-) Based Composite Tissue Engineering Scaffolds and Nonporous Thin Films. J Nanomater, vol. 2013, Article ID 479109, pp.1-8 (2013).

DOI: 10.1155/2013/479109

Google Scholar

[12] N. Sultana and M. Wang: PHBV/PLLA-based composite scaffolds fabricated using an emulsion freezing/freeze-drying technique for bone tissue engineering: surface modication and in vitro biological evaluation. Biofabrication Vol. 4 (2012).

DOI: 10.1088/1758-5082/4/1/015003

Google Scholar

[13] N. Sultana and T.H. Khan: In Vitro degradation of PHBV scaffold and nHA/PHBV composite scaffolds containing hydroxyapatite nanoparticle for bone tissue engineering. J. Nanomater. Vol. 2012 (2012).

DOI: 10.1155/2012/190950

Google Scholar