Hydration rata and temperature interaction is a complex problem. This paper focuses on variation of concrete hydration and its effect on temperature and stress filed simulation of concrete with cooling pipe. Through three-dimensional specified project with two methods that include consider effect of temperature on hydration rate and no consider effect of temperature on hydration rate, the computational results have been compared and the differences have been analyzed. So we advised that the temperature effect on hydration rate should been considered in temperature stress filed simulation of concrete with cooling pipe. It provide basis to the construction of mass concrete.