Indirect Determination of Acetylcysteine in Pharmaceutical Sample by Discoloration Spectrophotometry Using Fe(III)-Tiron System

Chang Qing Tu; Xin Rong Wen

doi:10.4028/www.scientific.net/AMM.713-715.2710

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 713-715Indirect Determination of Acetylcysteine in...

Indirect Determination of Acetylcysteine in Pharmaceutical Sample by Discoloration Spectrophotometry Using Fe(III)-Tiron System

Abstract:

Fe (Ш) can be reduced to Fe (II) by hydrosulfuryl (-SH) in acetylcysteine molecule,and then using tiron as chromogenic reagent of Fe (Ш),and the content of acetylcysteine is determinated indirectly through determinating the surplus content of Fe (Ш) in the system.An accurate fast spectrophotometric method for the determination of acetylcysteine by discoloration spectrophotometry using Fe (Ш)-tiron system has been established.This proposed method had been successfully applied to determinate of acetylcysteine in real pharmaceutical.

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Periodical:

Applied Mechanics and Materials (Volumes 713-715)

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2710-2713

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https://doi.org/10.4028/www.scientific.net/AMM.713-715.2710

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Online since:

January 2015

Authors:

Chang Qing Tu*, Xin Rong Wen

Keywords:

Acetylcysteine, Discoloration Spectrophotometry, Fe(III), Tiron

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