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Fabrication of Chitosan Nanofibers Scaffolds with Small Amount Gelatin for Enhanced Cell Viability

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Abstract:

Chitosan and gelatin has attracted considerable interest owing to its advantageous biological properties such as excellent biocompatibility, biodegradation, and non-toxic properties. In this paper, we investigated the potential of chitosan/gelatin (Chi-Gel) nanofibers mat with enhanced cell viability for use as cell culture scaffolds. The surface morphology, mechanical properties, and initial contact angle analysis of Chi-Gel nanofibers mat were evaluated. The proliferation of human dermal fibroblast cell (HDFs) on Chi-Gel nanofibers mat was found to be approximately 20% higher than the pure chitosan nanofibers mat after 7 days of culture. These results suggest that the Chi-Gel nanofibers mat has great potential for use tissue engineering applications.

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Periodical:

Applied Mechanics and Materials (Volume 749)

Pages:

220-224

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.749.220

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Online since:

April 2015

Authors:

Min Sup Kim, Sang Jun Park, Bon Kang Gu, Chun Ho Kim*

Keywords:

Cell Viability, Chitosan, Electrospinning, Gelatin, Scaffolds

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© 2015 Trans Tech Publications Ltd. All Rights Reserved

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