Synthesis of Poly(ethylene glycol)-Block-Poly(lactide) via Sequential Ring-Opening Polymerization Technique for Preparing Micellar Carriers

Chih Kuang Chen; Wen Jen Lin; Guan You Chen; Yu Te Lin; Rong Siou Jhu; Jia Horng Lin

doi:10.4028/www.scientific.net/AMM.749.433

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 749Synthesis of Poly(ethylene...

Synthesis of Poly(ethylene glycol)-Block-Poly(lactide) via Sequential Ring-Opening Polymerization Technique for Preparing Micellar Carriers

Abstract:

With the advancement of nanotechnology and material chemistry, micelles have emerged as one of the most attractive carriers for anticancer drug delivery. In this study, a newly developed polymerization technique termed as “sequential ring-opening polymerization (SROP)“ was used to synthesize poly (ethylene glycol)-block-polylactide-block-polylactide (PEG-PLA-PLAs). Utilizing the features of SROP, well-controlled chain length of two different PLA blocks by using PEG as initiator can be achieved. Two types of PEG-PLA-PLAs, PEG-PLA₁₁-PLA₁₁ and PEG-PLA₁₈-PLA₁₈, were successfully synthesized and characterized. Having amphiphilic properties, PEG-PLA-PLAs were used to form micelles through self-assembly. The effects of PLA length on the resultant micelles were thoroughly investigated.

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Periodical:

Applied Mechanics and Materials (Volume 749)

Pages:

433-436

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.749.433

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Online since:

April 2015

Authors:

Chih Kuang Chen, Wen Jen Lin, Guan You Chen, Yu Te Lin, Rong Siou Jhu, Jia Horng Lin

Keywords:

Cancer Diseases, Drug Carriers, Micelles, Poly(Ethylene Glycol)-Block-Poly(lactide), Sequential Ring-Opening Polymerization

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