Photocatalytic Effect of Metal Oxide Nanoparticles on Cultured Human Breast Cancer Cells

Abstract:

We have studied the photocatalytic effect of ZnO, TiO₂ and CuO nanoparticles under the different wavelength of the light irradiation on the cultured human breast cancer cell line. Each nanoparticle under the different wavelength of irradiation on the cells shows the different cell-killing effect. It is found that ZnO nanoparticles irradiated under the ultraviolet C are more pronounced toxicity than CuO nanoparticles irradiated under the visible light, and TiO₂ nanoparticles irradiated under the ultraviolet A, respectively. The intimate contact between the cell wall and the metal oxide nanoparticles under the appropriate light irradiation causes the changes in the environment in the vicinity of cell-nanoparticles contact area. This can generate the intracellular reactive oxidation species, partly due to the electron-hole pair, that tends to damage the nucleus of the cancer cells.

• Periodical: Applied Mechanics and Materials (Volume 851)
• Pages: 144-148
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.851.144
• Online since: August 2016
• Authors: Ladawan Suanlim, Suttijit Srivatcharakul, Kitsakorn Locharoenrat*
• Keywords: Cancer Cells, Nanoparticles, Photocatalyst, Reactive Oxidation Species, Semiconductors

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