Electrochemical Sensor Applications of Nanoparticle Modified Carbon Paste Electrodes to Detect Various Neurotransmitters: A Review

Abstract:

Neurotransmitters are synapses transmitting messengers that are vital towards human wellness. Any abnormality in their behaviour can lead to huge psychological ailments such as Parkinson's, Alzheimer's, and Schizophrenia. During diagnosing and assessing mental diseases, it is critical to discover distinct measures of different neurotransmitters present. A combination of nanomaterials, proteins, and polymers are employed to create suitable detecting and sensing component systems. Electrochemical detection has been widely employed for in-vivo detection, with FSCV emerging as the most promising technology to date due to advantages such as high sensitivities, simple device structure, and facile downsizing. Excessive background noise and signal, restricted target selectivity, declination with time, and the device fouling are all issues that in-vivo electrochemical neurotransmitter indications encounter. Nanomaterials have sparked a tremendous focus in recent years owing to their diverse properties. CPEs are amongst the safest and most ecologically beneficial electrodes with a vast scope of applications due to their incredibly simple and rapid manufacturing method, lower back - ground current, relatively inexpensive, adaptability to numerous modifiers and modifying techniques, so on and so forth.

• Periodical: Applied Mechanics and Materials (Volume 908)
• Pages: 69-88
• DOI: https://doi.org/10.4028/p-mizm85
• Online since: August 2022
• Authors: Rayappa Shrinivas Mahale*, Vasantha Kumar Shamanth, Krishna Hemanth, Rajendrachari Shashanka, P.C. Sharath, N.V. Sreekanth
• Keywords: Carbon Paste Electrode (CPE), Electrochemical Sensors, Fast-Scan Cyclic Voltammetry (FSCV), In Vitro Detection, In Vivo Detection, Neurotransmitter (NT)

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