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Stability Test and Storage of PDMS as a Biomaterial for Vitreous Humour Substitution in Vitreoretinal Surgery

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Abstract:

As a drug product for vitreous replacement, the stability of polydimethylsiloxane (PDMS) during storage is very necessary. PDMS must be stable both chemically and physically during the storage process according to WHO standards. This is necessary to maintain security and regulate the drug supply. Our research shows that low-and medium-viscosity PDMS produced from low-grade octamethylcyclotetrasiloxane (D4) monomer have good stability and storage for 15 months. The optimal time for stability and storage of this PDMS is 5 months. Changes in viscosity values occur due to a very slow chain growth from 5 until 15 months. However, a longer assessment time and other tests are needed to complete the material stability information.

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Info:

Periodical:

Applied Mechanics and Materials (Volume 915)

Pages:

25-30

DOI:

https://doi.org/10.4028/p-7MixRo

Citation:

Cite this paper

Online since:

August 2023

Authors:

Diba Grace Auliya, Nabillah Fa'diyyah Zahra, Soni Setiadji, Fitrilawati Fitrilawati, Arief Sjamsulaksan Kartasasmita, Risdiana Risdiana*

Keywords:

Low-Grade D4 Monomer, Low-Viscosity, Medium-Viscosity, PDMS, Stability, Storage

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© 2023 Trans Tech Publications Ltd. All Rights Reserved

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