According to the time-varying analysis theory of large-span structure hoisting, the structure transformation matrix around three-dimensional translation and rotation is obtained. Based on the obtained transformation matrix, the final state matrix after structure hoisting can be described, and the structural internal force of any position can be calculated. Using the Coin3d Open Inventor that is an open source graphics development kit, developers exploited simulation software of large-span structure hoisting. The software can analyze structural security with the time-varying analysis theory, and it has been applied in the simulation of hoisting construction at the Hefei Xinqiao international airport. The results indicated the software is reliable to protect safety of structure hoisting.